• AccuCor DTMS™

  • Thermaflux Scanner™

Brain Temperature Problem

“There is an assumption that core temperature and brain temperature are the same. With the introduction of brain temperature monitoring technology, it has become possible to examine the difference between core and brain temperatures. Fifteen studies from 1990 through 2002 found that brain temperature was higher than all measures of core temperature with mean differences of 0.39 to 2.5 degrees C.”
Comparison of brain temperature to core temperature: a review of the literature. McIlvoy L, J Neurosci Nurs. 2004 Feb; 36(1): 23-31.

There is a large and growing unmet need for accurate and continuous non-invasive monitoring of brain temperature. There are numerous clinical situations in which the temperature of the brain is intentionally lowered and then re-warmed by clinicians, and other situations in which the temperature of the brain climbs due to disease or injury. In all of these cases, accurate measurement of the actual temperature within the brain is critically important for the effective treatment and management of the patient.

Brain Temperature Solution

The AccuCor DTMS™ safely, accurately, and continuously monitors brain temperature. It is highly sensitive (capable of sensing one billionth of a watt) and measures microwave energy generated by heat originating five to seven centimeters deep within the body, allowing non-invasive temperature monitoring of deep brain tissue. The system is adapted from technology developed for space-based radio telescopes and incorporates a unique and proprietary focused-beam antenna.

A Childhood Problem

Vesicoureteral Reflux (VUR) is a condition in which bladder urine flows backwards through the ureters and into the kidneys, exposing the kidneys to infection. Globally, VUR occurs in more than ten million children under five and can cause irreparable kidney damage if untreated. Untreated VUR can lead to severe kidney scarring, stunted kidney growth, kidney atrophy, and in severe cases, kidney failure requiring dialysis or kidney transplantation. Additionally, untreated VUR can lead to lifelong health conditions such as high blood pressure, renal impairment, renal failure, and complications in pregnancy as an adult.

Unfortunately, the current procedures used for detecting VUR are highly invasive and very traumatic for children. A voiding cystourethrogram (VCUG) is a technique for watching a patient’s urethra and urinary bladder while the patient urinates (voids). The technique consists of inserting a catheter through the urethra and into the bladder of the child in order to fill the bladder with a radiocontrast agent. This is a very painful and traumatic procedure for a child to endure. Under fluoroscopy (real time x-rays), a radiologist watches the contrast enter the bladder and looks at the anatomy of the child. If the contrast moves into the ureters and back into the kidneys, the radiologist makes the diagnosis of vesicoureteral reflux, and gives the degree of severity a score. The exam ends when the child voids while the radiologist is watching under fluoroscopy. It is important to watch the contrast during voiding, because this is when the bladder has the highest pressure and is most likely to result in VUR.

The Solution for Children

ThermImage has developed an alternative to the current diagnostic tests for VUR. The Thermaflux Scanner™ provides a noninvasive, safe, reliable, comfortable and cost effective imaging test for detecting pediatric VUR. The new device will eliminate a majority of the VCUG and nuclear cystogram procedures used to detect VUR, increase the detection rate, reduce the usage of unnecessary antibiotics, and help prevent potentially devastating health consequences later in life.

The Thermaflux Scanner™ provides a safe, non-traumatic, noninvasive procedure that, unlike current procedures, does not require catheterization or expose the child to harmful radiation or contrast agents in order to diagnose pediatric VUR. Performed externally, the process warms the bladder contents and monitors the kidney temperatures to reveal if VUR is present. The process also improves patient care by diagnosing VUR at physicians’ offices as well as at hospitals, significantly expanding the market and eliminating the risk that kidney damage may occur prior to the child being diagnosed at a hospital.